Natural Licorice Root Extract for Radiant Skin Brightening

• Certification: Hala
• Assay Method: HPLC
• Application Form: Injection, Lotion, Suppository, Paste, Tablet, Capsule
• Model NO.: JT-320
• Application: Health Care Products, Medicine, Cosmetics
• State: Powder
• Transport Package: 25kgs/Drum or Carton, Inner by Aluminum Foil Bag
• Specification: 10%, 40%, 70%, 90%, 98%
• Origin: China
• HS Code: 1302199099
• Production Capacity: 1000kg/Month

Product Description

Product name	Glabridin
Appearance	Brown powder was used for low content and white powder for high content
CAS	59870-68-7
Test Method	HPLC
Molecular Formula	C20H20O4
Molecular Weight	324.3704
EINECS	611-908-7

Glabridin
Glabridin is one of the main flavonoids in Glycyrrhiza glabridin. It shows a strong anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, and can significantly inhibit the free radicals produced in the process of metabolism in the body, so as to avoid the oxidation-sensitive biological macromolecules (low-density lipoprotein LDL,DNA) and cell wall oxidative damage by free radicals. Thus, some pathological changes related to free radical oxidation can be prevented and treated, such as atherosclerosis and cellular senescence. In addition, glabridin also had the effect of lowering blood lipids and blood pressure. The Italian study also confirmed that Glabridin has an appetite suppressant effect, which can reduce fat without reducing weight. After repeated trials, mainly by the following functions: whitening, inhibition of melanin; 2: anti-inflammatory effect 3: antioxidant effect 4: antibacterial effect.
Specification:  10%,40%,70%,90%,98%
Solubleness:Insoluble in water, soluble in butanediol, propylene glycol and other organic solvents
It inhibits tyrosinase
Human tyrosinase is an essential enzyme that regularly produces melanin, which turns the skin or eyes from brown to black. It is known that skin exposure to UV light can cause some reactions (such as inflammation). This histological change is manifested as erythema and pigmentation due to the destruction of the phospholipid membrane of the skin tissue by UV-induced reactive oxygen species. Reactive oxygen species (ROS) are substances that cause skin pigmentation, so inhibiting its production can inhibit the production of melanin. Glabridine is the most expensive and most effective whitening ingredient among all whitening ingredients. According to the Chinese Herbal Medicine, the whitening effect of glabridine is 232 times that of ordinary vitamin C, 16 times higher than that of hydroquinone, and 1164 times that of arbutin, so glabridine is called "whitening gold".
Anti-inflammatory effect
The anti-inflammatory activity of glabridin was verified by applying 0.5% glabridin solution to guinea pigs with UV-induced hyperpigmentation. It was found that glabridin alleviated UV-induced skin inflammation. The a value is used to indicate the erythema on the skin. The degree of inflammation reduction could be calculated by recording the a value of glabridin before irradiation, after irradiation, and after the use of glabridin (the reading from the colorimeter). The inhibition of cyclooxygenase activity by glabridin was studied. Cyclooxygenase is an enzyme that converts arachidonic acid to prostaglandins, which are inflammatory agents. Cyclooxygenase was inhibited by glabridin compared with the control group (treated with the current cyclooxygenase inhibitor, indomethacin). It is believed that glabridin affects arachidonic acid production by inhibiting cyclooxygenase, thereby reducing inflammation.
Antioxidant effect
Glabridin has a strong scavenging effect of free radicals, vitamin C, vitamin E and β-carotene are recognized as the king of the three antioxidant anti-aging, glabridin its anti-aging ability and vitamin E is equivalent, is a natural antioxidant, it is reported that its antioxidant effect is significantly better than BHA and BHT. [3] It has been reported that licorice can be used to reduce the corticosteroids of infectious skin diseases and can enhance the action of steroids.