Natural Extract Antioxidant Properties Devil′s Claw Extract Powder CAS 19210-12-9 1%-5%Harpagoside

• Certification: Hala
• Assay Method: HPLC, Tlc
• Application Form: Injection, Tablet, Capsule
• Model NO.: JT-235
• Application: Health Care Products, Medicine
• State: Powder
• Extract Source: Devil′sclaw
• CAS: 19210-12-9
• Molecular Formula: C24h30o11
• Molecular Weight: 494.49
• Transport Package: 25kgs/Drum or Carton, Inner by Aluminum Foil Bag
• Specification: 4: 1 10: 1 1%-5%Harpagoside
• Origin: China
• HS Code: 1302199099
• Production Capacity: 1000kg/Month

Product Description

Product name	Devil'sClaw Extract Powder
Appearance	Yellow Brown fine powder
CAS	19210-12-9
Test Method	HPLC/TLC
Molecular formula	C24H30O11
Molecular weight	494.49

Devil'sClaw Extract
The main active ingredient of the extract of Uncaria gracilis is Harpagoside. This product is derived from the roots of Uncaria gracilis, a perennial herb of the Flaxaceae family in southern Africa. Molecular formula :C24H30O11.
This product is used for the treatment of bronchial asthma, ulcerative colitis, local ileitis, rheumatic disorders, and indications for elevated lipoxygenase levels caused by drugs, other substances or disorders. It has anti-inflammatory, analgesic, anti-rheumatic, antioxidant activities, digestive promotion effects, and immune regulation functions.

Specification:  4:1  10:1

1.5-Lipoxygenase biosynthesis inhibition activity: In in vitrostudies, and two carbon dioxide extracts totally inhibited 5-lipoxygenasebiosynthesis at a concentration of 51.8mg/L, although a convention extract didnot show any inhibition.

2.Analgesic properties: Administration of 20mg/kg harpagoside has beenreported to produce an analgesic effect similar to that of phenylbutazone at50mg/kg. Writhings and stretchings induced in rats by 1.2% acetic acid wassignificantly reduced after administration of an aqueous devil's claw extract(2.2% harpagoside).6An aqueous Harpagphytum root extract given byintraperitoneal administration (200mg/kg) produced 53% protection.3

3.Antimicrobial properties: A crude preparation of H. procumbensdemonstrated antiplasmodial activity5

4.Antioxidant properties: Antioxidant effects similar to selegiline-inducedresponses were found in rats treated with a 53% ethanolic Harpagophytum dryextract2Some animal experiments have reported antioxidant activity of H. procumbens22,23,although these results have not been confirmed by others5,39.